Granulation | Tablet & Sterilization Machines - Pharmaceutical Manufacturing Equipment | Yenchen

High Shear Mixer | Yenchen Machinery Co., Ltd. has been specializing in manufacturing Pharmaceutical Machine for 60 years.

High Shear Mixer

Granulation

Source : Yenchen Technical Process Consultant, Dr. Fred Rowley


The Curve Doesn't Tell The Whole Story

We Begin By Discussing The Curve


  • i = Mixing dry powder
  • ii = Adding the granulating solution (Binder).
  • iii = The period after the binder is added but before resistance begins.
    Resistance is linked to binder/powder fusion.
  • iv = Resistance builds as more and more granules are formed from the binder/powder fusion.
  • v = End of granule growth.

High Shear Wet Granulating: The "Rules" or Critical Operating Parameters (This Graph Does Not Address)

A. Method of loading the granulator
B. Fill level (Occupancy)
C. The Nature of the granulating solvent/suspension
D. The method of adding the granulating solution
E. Impeller speed
F. Chopper speed, use of the chopper
G. Post addition granulating time
H. Method of unloading the granulator
I. Scraping down the vessel

➢ A. Method of Loading the Granulator

  • Because there is limited vertical mixing, what goes in first tends to stay at the bottom of the vessel.
  • What goes in last, tends to stay at the top of the vessel (or stick on the lid, see below).
  • Layering of key materials is often done.

Conclusion

  • You don't just rely on a gauge.
  • If you insist and just rely on a gauge then chances are you are doing something wrong.
  • The greater the number of products, the more likely you are doing something wrong.

If you have any technical questions, please contact with Grace Chiang Email:grace.chiang@yenchen.com.tw
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Granulation | Tablet & Sterilization Machines - Pharmaceutical Manufacturing Equipment | Yenchen

Located in Taiwan since 1967, YENCHEN MACHINERY CO., LTD. has been a pharmaceutical manufacturing equipment supplier in pharmaceutical industry. Their main manufacturing and processing equipment include, hot air sterilizers, extrusion machines, tablet coating and compression machines, pellet making machines and oral solid dosage manufacturing equipment, which are sold to over 70 countries meeting international standards.

Yenchen was established in 1967, our products and services are widely used in the pharmaceutical, food, biotechnology, chemical, and cosmetic fields, which include solid dosage line, pellet machine production line, syrup line, injection line, ointment line, extraction & concentration turnkey equipments.

Yenchen has been offering customers high-quality pharmaceutical manufacturing equipment since 1967, both with advanced technology and 57 years of experience, Yenchen ensures each customer's demands are met.