Aqueous Film Coating, Mixing and Holding Coating Solutions - 2 | Tablet & Sterilization Machines - Pharmaceutical Manufacturing Equipment | Yenchen

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Aqueous Film Coating, Mixing and Holding Coating Solutions - 2

Source : Yenchen Technical Process Consultant, Dr. Fred Rowley


Proper Ratio of Prop Diameter To Vessel Diameter

1. Use a high efficiency propeller stirrer with a diameter equivalent to 25-30% of the diameter of the mixing vessel.
2. Solution preparation practices are often over looked or discredited as a source of process variation but are critical for success.

How Many Props To Use?

1. One prop is placed at the top of the shaft, near the surface of the liquid.

2. The second prop is placed at the bottom of the shaft.

3. This configuration can produce the vortex that is required to draw in powder or liquid materials.

4. In general, dual props will also be required in any container whose height is greater than 1.5 times its diameter.

How Close To The Bottom of The Tank?

* Use the rule of thumb for prop mixers is to position the mixer propeller 1 to 2 propeller diameters from the bottom of the tank.

Where To Place The Mixer?

1. Effective mixing patterns are achieved when the mixer is angled 10 to 15 degrees away from the vertical, either off-center or on-center in the tank.

2. An on-enter angle (vertical position with zero angle) is better for simple formulas (film / plasticizer / T<sub>1</sub>O<sub>2</sub>). It will create a vortex and some foam.

  * Vortex occurs when the contents of the tank swirl around the walls of the tank without much top-to-bottom turnover, this results in a less-efficient mixing operation and the possibility of uneven mixing or blending.

3. Positioning or angling a mixer 15 to 20 degrees off of the tank's centerline is preferred when mixing a slurry like coating formula (film / plasticizer / two or more dyes / large quantity of T<sub>1</sub>O<sub>2</sub>).

4. If you are using both types of coating solutions, use the off center position or consider a Homogenizer.


If you have any technical questions, please contact with Grace Chiang Email:grace.chiang@yenchen.com.tw
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Aqueous Film Coating, Mixing and Holding Coating Solutions - 2 | Tablet & Sterilization Machines - Pharmaceutical Manufacturing Equipment | Yenchen

Located in Taiwan since 1967, YENCHEN MACHINERY CO., LTD. has been a pharmaceutical manufacturing equipment supplier in pharmaceutical industry. Their main manufacturing and processing equipment include, hot air sterilizers, extrusion machines, tablet coating and compression machines, pellet making machines and oral solid dosage manufacturing equipment, which are sold to over 70 countries meeting international standards.

Yenchen was established in 1967, our products and services are widely used in the pharmaceutical, food, biotechnology, chemical, and cosmetic fields, which include solid dosage line, pellet machine production line, syrup line, injection line, ointment line, extraction & concentration turnkey equipments.

Yenchen has been offering customers high-quality pharmaceutical manufacturing equipment since 1967, both with advanced technology and 57 years of experience, Yenchen ensures each customer's demands are met.