YENCHEN MACHINERY CO., LTD. - Yenchen Machinery - leading pharmaceutical machinery manufacture in Taiwan

FAQs | Six Common Problems: Issues That May Affect MUPS | Manufacturing Equipment for Pharmaceutical Industry | Yenchen

Yenchen is a high-quality Solid Dosage Line, Pellet Machine Production Line, Syrup Line, Injection Line, Ointment Line, Extraction & Concentration Turn Key Equipments supplier from Taiwan since 1967. Yenchen was established in 1967, our products and services are widely used in the pharmaceutical, food, biotechnology, chemical, and cosmetic fields, which include solid dosage line, pellet machine production line, syrup line, injection line, ointment line, extraction & concentration turnkey equipments.

Six Common Problems: Issues That May Affect MUPS | Tablet & Sterilization Machines - Pharmaceutical Manufacturing Equipment | Yenchen

Six Common Problems: Issues That May Affect MUPS | Yenchen Machinery Co., Ltd. has been specializing in manufacturing Pharmaceutical Machine for 60 years.

Six Common Problems: Issues That May Affect MUPS

Six Common Problems: Issues That May Affect MUPS

Source : Yenchen Technical Process Consultant, Dr. Fred Rowley

Problem One: First Weight, Then Hardness, Then Thickness


Problem Two: MUPS Blends Tend to Be Cohesive


Problem Three: Bead and Powders, as a Blend, Easily Segregate


  • Many studies have shown that vibrations or rotation of a granular material will induce particles of different sizes to separate into different regions of the container.

Problem Four: MUPS Blends Tend To Laminate


Six root causes:
  • Uneven compressing over the face of the upper punch.
  • Non optimized head used on the upper punch.
  • Compressing the tablet too thin at very low press speed.
  • Pressure is appropriate for the beads but not the powder.
  • Punch tips are cracked and this transfers to the tablet.
  • New punches

Problem Five: MUPS Beads May Migrate During Compressing


Due To Press Speed and Centrifugal Force
  • Depending upon the difference in the bulk densities between the beads/excipients, the effect of turret speed may range from minor to significant.
  • Bends have been reported to migrate to the top center of the tablet and also to the top center and bottom corner of oval and capsule shaped tablets.

Problem Six: MUPS Bead May Be Caught Between Feeder and The Die Table


  • Beads can be damaged or broken when pressed between the feeder base and/or the "tail over the die" and the die table.



If you have any technical questions, please contact with Grace Chiang Email:grace.chiang@yenchen.com.tw
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Six Common Problems: Issues That May Affect MUPS | Tablet & Sterilization Machines - Pharmaceutical Manufacturing Equipment | Yenchen

Located in Taiwan since 1967, YENCHEN MACHINERY CO., LTD. has been a pharmaceutical manufacturing equipment supplier in pharmaceutical industry. Their main manufacturing and processing equipment include, hot air sterilizers, extrusion machines, tablet coating and compression machines, pellet making machines and oral solid dosage manufacturing equipment, which are sold to over 70 countries meeting international standards.

Yenchen was established in 1967, our products and services are widely used in the pharmaceutical, food, biotechnology, chemical, and cosmetic fields, which include solid dosage line, pellet machine production line, syrup line, injection line, ointment line, extraction & concentration turnkey equipments.

Yenchen has been offering customers high-quality pharmaceutical manufacturing equipment since 1967, both with advanced technology and 58 years of experience, Yenchen ensures each customer's demands are met.