
Multiple Unit Pellet Systems(MUPS)
Source : Yenchen Technical Process Consultant, Dr. Fred Rowley
Advantages:
- General technology applicable for a wide range of drugs
- No dose dumping
- Reduction of irritation of the gastric mucosa
- Great range of release rates possible
- Predictable bioavailability
- Minimized fluctuations in plasma concentration of drug
- High dose strength administration
- Reduces the esophageal residence time, compared with hard gelatin capsules
Disadvantages:
- Hard to manufacture when compared to other available technologies
- Somewhat pH dependent, which is not be an issue with OROS
- Coating conditions may influence release rates
- Not all tablet presses will successfully compress MUPS
- Weight variation, poor hardness, and friability
- Potential content segregation of coated pellets in the tableting blend
If you have any technical questions, please contact with Grace Chiang Email:grace.chiang@yenchen.com.tw
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