
Multiple Unit Pellet Systems(MUPS)
Source : Yenchen Technical Process Consultant, Dr. Fred Rowley
Advantages:
- General technology applicable for a wide range of drugs
 - No dose dumping
 - Reduction of irritation of the gastric mucosa
 - Great range of release rates possible
 - Predictable bioavailability
 - Minimized fluctuations in plasma concentration of drug
 - High dose strength administration
 - Reduces the esophageal residence time, compared with hard gelatin capsules
 
Disadvantages:
- Hard to manufacture when compared to other available technologies
 - Somewhat pH dependent, which is not be an issue with OROS
 - Coating conditions may influence release rates
 - Not all tablet presses will successfully compress MUPS
 - Weight variation, poor hardness, and friability
 - Potential content segregation of coated pellets in the tableting blend
 
If you have any technical questions, please contact with Grace Chiang Email:grace.chiang@yenchen.com.tw
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