YENCHEN MACHINERY CO., LTD. - Yenchen Machinery - leading pharmaceutical machinery manufacture in Taiwan

FAQs | General Critical Parameters in The Blending Cycle Used in Successful Scale Up | Manufacturing Equipment for Pharmaceutical Industry | Yenchen

Yenchen is a high-quality Solid Dosage Line, Pellet Machine Production Line, Syrup Line, Injection Line, Ointment Line, Extraction & Concentration Turn Key Equipments supplier from Taiwan since 1967. Yenchen was established in 1967, our products and services are widely used in the pharmaceutical, food, biotechnology, chemical, and cosmetic fields, which include solid dosage line, pellet machine production line, syrup line, injection line, ointment line, extraction & concentration turnkey equipments.

General Critical Parameters in The Blending Cycle Used in Successful Scale Up | Tablet & Sterilization Machines - Pharmaceutical Manufacturing Equipment | Yenchen

Double Cone Mixer | Yenchen Machinery Co., Ltd. has been specializing in manufacturing Pharmaceutical Machine for 60 years.

Double Cone Mixer

General Critical Parameters in The Blending Cycle Used in Successful Scale Up

Source : Yenchen Technical Process Consultant, Dr. Fred Rowley

  • Type (class) of blender Used
  • “Fill Level”, Quantity of powder to be blended
    There is agreement that each blender class has a minimum and a maximum fill and also that exceeding these limits will produce an ever increasing and finally unacceptable content uniformity variation.
    Current knowledge and experience produces the following recommendation:
    Drum Blender: 55%
    Twin shell: 45-70% range
    Double cone: 40-65% range
    IBC Blender: 40-65% range
    Octagonal Blender: 45-75% range
  • The method of loading the blender
  • The use of pre-blending
  • The use of an intensifier bar/agitator/baffle
    Secondary mixing with a higher intensity devise is sometimes needed to break up “hot spots” and at times lumps.
    This is especially important when using an IBC or an Octagonal blender.
  • Mixing time
  • Lubricant blending time
  • The method of unloading the blender



If you have any technical questions, please contact with Grace Chiang Email:grace.chiang@yenchen.com.tw
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General Critical Parameters in The Blending Cycle Used in Successful Scale Up | Tablet & Sterilization Machines - Pharmaceutical Manufacturing Equipment | Yenchen

Located in Taiwan since 1967, YENCHEN MACHINERY CO., LTD. has been a pharmaceutical manufacturing equipment supplier in pharmaceutical industry. Their main manufacturing and processing equipment include, hot air sterilizers, extrusion machines, tablet coating and compression machines, pellet making machines and oral solid dosage manufacturing equipment, which are sold to over 70 countries meeting international standards.

Yenchen was established in 1967, our products and services are widely used in the pharmaceutical, food, biotechnology, chemical, and cosmetic fields, which include solid dosage line, pellet machine production line, syrup line, injection line, ointment line, extraction & concentration turnkey equipments.

Yenchen has been offering customers high-quality pharmaceutical manufacturing equipment since 1967, both with advanced technology and 57 years of experience, Yenchen ensures each customer's demands are met.