YENCHEN MACHINERY CO., LTD. - Yenchen Machinery - leading pharmaceutical machinery manufacture in Taiwan

FAQs | A Detailed Discussion of Blend Times and Lubricating Times | Manufacturing Equipment for Pharmaceutical Industry | Yenchen

Yenchen is a high-quality Solid Dosage Line, Pellet Machine Production Line, Syrup Line, Injection Line, Ointment Line, Extraction & Concentration Turn Key Equipments supplier from Taiwan since 1967. Yenchen was established in 1967, our products and services are widely used in the pharmaceutical, food, biotechnology, chemical, and cosmetic fields, which include solid dosage line, pellet machine production line, syrup line, injection line, ointment line, extraction & concentration turnkey equipments.

A Detailed Discussion of Blend Times and Lubricating Times | Tablet & Sterilization Machines - Pharmaceutical Manufacturing Equipment | Yenchen

blending | Yenchen Machinery Co., Ltd. has been specializing in manufacturing Pharmaceutical Machine for 60 years.

blending

A Detailed Discussion of Blend Times and Lubricating Times

Source : Yenchen Technical Process Consultant, Dr. Fred Rowley

A Detailed Discussion of Blend Times:

Goal One: Perfect Content Uniformity

Materials go from an unmixed state to a state of relative homogeneous consistency. Achieving a homogeneous blend is accomplished through a combination of time and mechanical energy. Given enough time, components will pass from an unblended state to a relatively homogenous blend and back to an unblended state. Blend studies determine the optimum endpoint. All blends have a unique pathway to their optimum state of uniformity.
blending time & minutes

Goal Two: Perfect (Not Precise) Lubricant Distribution

  • Insufficient blending of the lubricant is confirmed with tablets having (sometimes) picking and sticking and ejection problems with some portions of the blend while having (sometimes) tablet lamination combined with soft tablets with other portions of the same blend.
  • Excessive blending of the lubricant is confirmed with tablets having lamination/soft tablets throughout the entire batch. Tablets in many cases cannot achieve even minimum specification hardness. Lamination may occur in both the upper and lower regions of the tablet. Disintegration may or may not be affected and dissolution may be bad even when the disintegration is good.

lubricant blending time



If you have any technical questions, please contact with Grace Chiang Email:grace.chiang@yenchen.com.tw
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A Detailed Discussion of Blend Times and Lubricating Times | Tablet & Sterilization Machines - Pharmaceutical Manufacturing Equipment | Yenchen

Located in Taiwan since 1967, YENCHEN MACHINERY CO., LTD. has been a pharmaceutical manufacturing equipment supplier in pharmaceutical industry. Their main manufacturing and processing equipment include, hot air sterilizers, extrusion machines, tablet coating and compression machines, pellet making machines and oral solid dosage manufacturing equipment, which are sold to over 70 countries meeting international standards.

Yenchen was established in 1967, our products and services are widely used in the pharmaceutical, food, biotechnology, chemical, and cosmetic fields, which include solid dosage line, pellet machine production line, syrup line, injection line, ointment line, extraction & concentration turnkey equipments.

Yenchen has been offering customers high-quality pharmaceutical manufacturing equipment since 1967, both with advanced technology and 57 years of experience, Yenchen ensures each customer's demands are met.