Film Chipping or Edging
Source : Yenchen Technical Process Consultant, Dr. Fred Rowley
Problem :
- Too much agitation
Root Causes :
- API is very brittle and comprises a large part of the tablet
ㆍPentoxifylline
ㆍRanolizine - Overblending of the lubricant (compressing)
- Sharp tablet edges
- Highly friable tablet cores (partial caps)
- Weak film
- Poor film elasticity
- Sharp object in the coating pan.
- Inappropriate coating conditions : Excessive pan speed
- Wrong baffles!!!
- Unloading problems
- Wrong (absent) baffle reduction plate
If you have any technical questions, please contact with Grace Chiang Email:grace.chiang@yenchen.com.tw
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