In the larger picture, pre-compression tablet thickness is part of the pre-compression station that is used to remove residual air left in the powder blend after final powder blending. Part of our understanding must include a review of the blending step, specifically, powder behavior after blending is completed and before tablet manufacturing begins.

During component blending, air is trapped between the various particles of a complex formula (often with six or more separate components, including the active ingredient). This air is a result of many factors, including the number of components, the morphology of the individual components, the type of blender used, relative fill level in the blender, length of the blending time, the manner of powder evacuation, and static electricity generated.

In addition, a basic understanding of the nature of the powder percolation pattern immediately after blending stops is critical for both obtaining reliable blend samples used to defend blending parameters and for the optimized hold time of the blend before tablet compression.

Once we have this information, we are better prepared to set relevant control settings for the pre-compression thickness control. In the absence of this information and without significant operator training and guidance, we are to some extent "guessing" what control setting is best.


If you have any technical questions, please contact with Grace Chiang Email:grace.chiang@yenchen.com.tw
Copyright © 2019 YENCHEN MACHINERY CO., LTD. All Rights Reserved.